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This Concept Map, created with IHMC CmapTools, has information related to: Acute Psychosis- Dawson Case Study, Olanzapine olanzapine blocks serotonin 5-HT2 receptors in the mesocortical pathway 5-HT2A receptor, Prolactin Haloperidol can increase prolactin levels via its effects on the tuberinfundibular pathway, leading to milk secretion in women. Haloperidol, Negative symptoms Negative symptoms typically include Blunted affect, Glutamate Mutations in a glutamate receptor can result in sx consistent with a psychotic episode Psychotic episode, Jack Dawson is a 25-year-old Caucasian male Pt's drug screen was positive for the presence of PCP PCP (Phencyclidine), Dopamine DA binds to the D2 receptor, and D2 antagonists are the mechanism of typical antipsychotics D2 receptor, Hypothyrodism Severe, untreated hypothyrodism can manifest as myxdemia psychosis. Myxedema psychosis, Positive symptoms Hyperactivity of dopamine in the mesolimbic pathway mediates positive psychotic symptoms. The pathway may also mediate aggression. Mesolimbic pathway, Nigrostriatal pathway DA actions at the nigrostriatal pathway are associated with voluntary movements Dopamine, Negative symptoms Decreased dopamine in the mesocortical projection to the dorsolateral prefrontal cortex is postulated to be responsible for negative and depressive symptoms of schizophrenia Mesocortical pathway, Tuberoinfundibular pathway Typical antipsychotics block D2 receptors in the tuberinfundiblar pathway, leading to increased prolactin release. Therefore, an adverse effect would be menstrual irregularities. Prolactin, 5-HT2A receptor 5-HT2A receptor is bound by Serotonin and is the target of atypical antipsychotics, which treat both positive and negative symptoms in schizophrenia Serotonin, G protein-coupled receptor Dopamine receptors are members of the G-protein-coupled receptor (GPCR) superfamily Dopamine, Haloperidol Haloperidol lowers dopamine levels in the mesolimbic pathway Dopamine, Myxedema psychosis presents as Delusions, Delusions a false belief that is maintained even if there is evidence to disprove it Positive symptoms, Myxedema psychosis presents as Hallucinations, Hyperthyroidism In addition to physical symptoms, pt also can experience Delusions, Mesocortical pathway olanzapine blocks serotonin 5-HT2 receptors in the mesocortical pathway 5-HT2A receptor, D2 receptor Excess D2 activation can lead to positive sx including delusions and hallucinations Delusions